Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation.
نویسندگان
چکیده
The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 μM, respectively.
منابع مشابه
[Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 22 11 شماره
صفحات -
تاریخ انتشار 2012